1. WHAT IS NMN (NICOTINAMIDE MONONUCLEOTIDE)?
NMN, a substance similar to a vitamin whose official name is "nicotinamide mononucleotide," was discovered in the 1930s by German scientists in their studies of yeast and enzymes.
It is originally found in various living organisms, including humans, and is also produced by the body. However, it is said to be gradually lost as we age. And as a result, our energy for activity is weakened, which is believed to affect our physical condition.
When we hear about cutting-edge ingredients, we may feel a little scared to take them in supplements or skin care, but in fact, they are originally found in our body and are also present in nature.
1-1. NMN, THE KEY TO YOUTHFULNESS AND HEALTH MAINTENANCE
NMN has recently been reported to be related to the sirtuin gene, also known as the longevity gene, and oral ingestion or application of NMN to the skin increases the amount of NMN in the cells and activates the sirtuin gene. As a result, it is believed to lead to the suppression of aging.
This announcement has led to an increased interest in NMN among researchers around the world.
NMN, which has been reported to help maintain a youthful and healthy physical condition, is a rare ingredient that is attracting attention as a key to anti-aging and anti-aging care.
1-2. RESEARCH REPORTS SHOW GROWING EXPECTATIONS FOR NMN'S REJUVENATION EFFECT.
PROFESSOR DAVID SINCLAIR OF HARVARD MEDICAL SCHOOL, A RENOWNED NMN RESEARCHER, REPORTED THE RESULTS OF A STUDY IN WHICH "MICE TWO YEARS OLD (ABOUT 60 HUMAN YEARS OLD) WERE GIVEN NMN FOR ONE WEEK AND WERE REJUVENATED TO THE ATHLETIC PERFORMANCE, APPEARANCE, AND CELL ACTIVITY LEVELS OF SIX MONTHS OLD (ABOUT 20 HUMAN YEARS OLD).
1-3. NASA ASTRONAUTS ALSO TAKE NMN
NASA (National Aeronautics and Space Administration) has announced that astronauts returning from the space station are being given NMN to ingest.
In space, electromagnetic radiation such as X-rays and gamma rays are flying around, and the particle radiation contained in them is constantly falling. Astronauts are exposed to cosmic radiation as they carry out their missions in space. Aging and cell damage, which can trigger health problems related to muscle and memory, are very serious problems. So NMN is being adopted as a solution to this problem.
1-4. NMN IS ALSO FOUND IN FOOD, BUT...
NMN can also be obtained from breast milk and vegetables, but in very small amounts.
For example, to consume 100 mg of NMN, one must eat 33,000 grains (about 21 kg) of edamame and 2,000 bunches (about 40 kg) of broccoli daily, even from vegetables that are particularly rich in NMN.
Other vegetables such as avocados, tomatoes, cabbage and shrimp also contain NMN, but given that they contain less NMN than edamame and broccoli, it is difficult to get enough from food to reduce aging.
2. NMN CAN COMPENSATE FOR THE DECREASE IN NAD+, THE KEY TO YOUTHFULNESS, WHEN INGESTED.
NMN is converted into a coenzyme called NAD+ in the body when taken as a supplement, etc. NAD+ is responsible for maintaining the body functions of all living organisms and keeping them energetic and energetic.
However, like NMN, NAD+ also declines in the body as we age, and our bodies deteriorate as energy production declines accordingly.
In today's age of "120-year life expectancy," it is important to extend our healthy life span.
Although aging is inevitable, it is essential to increase the amount of NAD+ in the body and prevent the decline in energy production in order to stay active and energetic.
2-1. WHAT IS "NAD+" IN OUR BODY?
NAD+ is officially called "nicotinamide adenine dinucleotide" and is a chemical change of niacin, a type of vitamin.
NAD+ has been noted for its association with aging and is believed to decline as we age, causing our bodies to deteriorate.
It is also believed that supplementation with NAD+ activates the "sirtuin gene," a well-known longevity gene, and helps in anti-aging.
2-2. NAD+ IS BEST SUPPLEMENTED WITH NMN!
IF AGING IS CAUSED BY A DECREASE IN NAD+, WHY NOT JUST TAKE NAD+ DIRECTLY TO COMPENSATE? ONE WOULD THINK SO, WOULDN'T ONE? HOWEVER, NAD+ HAS A LARGE MOLECULAR STRUCTURE AND IS NOT EASILY ABSORBED INTO THE BODY EVEN WHEN TAKEN ORALLY. THIS IS WHERE NMN COMES IN: NMN, WHICH HAS A SMALLER MOLECULAR STRUCTURE THAN NAD+, IS MORE EASILY ABSORBED AND CONVERTED TO NAD+ IN THE BODY, MAKING SUPPLEMENTATION WITH NMN MORE EFFICIENT.
3. NMN IS UPWARDLY COMPATIBLE WITH NIACINAMIDE, A POPULAR ANTI-WRINKLE INGREDIENT: ⁉︎
Niacinamide has recently been included in serums and other products as an anti-wrinkle ingredient. Niacinamide is also converted to NAD+ by oral intake or application to the skin.
However, compared to NMN, which can be converted directly to NAD+, niacinamide undergoes a two-step process before being converted to NAD+, so the final amount of NAD+ is less.
Niacinamide itself is a high-quality ingredient, but if you are going to go to the trouble of taking it, we recommend NMN, which converts more efficiently to NAD+.
3-1. THE LEADING EXPERTS IN ANTI-AGING RESEARCH ALSO FAVOR NMN!
SUBSTANCES SIMILAR TO NMN INCLUDE NIACIN (NA) AND NICOTINAMINORIBOSIDE (NR), BUT PROFESSOR SHINICHIRO IMAI OF THE UNIVERSITY OF WASHINGTON, A LEADING RESEARCHER ON THE ANTI-AGING AND OTHER EFFECTS OF NMN, IS OF THE OPINION THAT "NEITHER IS EFFICIENT.
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Interviewer:
NMN SUPPLEMENTS ARE QUITE EXPENSIVE; I UNDERSTAND THAT NMN IS MADE FROM NIACIN, BUT CAN I SUBSTITUTE INEXPENSIVE NIACIN SUPPLEMENTS?
Professor Imai:
IF THERE IS SOME DISEASE AND NAD, WHICH IS ESSENTIAL FOR ENERGY PRODUCTION, IS THOUGHT TO BE REDUCED, NIACIN ALONE MAY BE EFFECTIVE. HOWEVER, BE AWARE THAT LARGE DOSES OF NIACIN CAN CAUSE SIDE EFFECTS SUCH AS LIVER DAMAGE AND IMPAIRED EFFECTIVENESS OF INSULIN, WHICH IS SECRETED BY THE PANCREAS.
Interviewer:
AS A NIACIN-DERIVED SUPPLEMENT THAT SYNTHESIZES NAD, "NR (NICOTINAMIDE RIBOSIDE)" SEEMS TO BE POPULAR IN THE US, BUT WHICH IS BETTER, NR OR NMN?
Professor Imai:
ANTI-AGING RESEARCH USING NR IS ALSO BEING CONDUCTED AROUND THE WORLD, AND VARIOUS ANTI-AGING EFFECTS HAVE BEEN REPORTED IN MICE, INCLUDING IMPROVEMENTS IN METABOLISM AND COGNITIVE FUNCTIONS. UNFORTUNATELY, HOWEVER, THERE ARE NO REPORTS OF ANTI-AGING EFFECTS IN HUMANS. NMN IS ALSO DEGRADED BY INTESTINAL BACTERIA, BUT BEFORE THAT, IT IS TAKEN UP INTO THE BLOODSTREAM AND CONVERTED TO NAD AT A VERY FAST RATE. OUR BODY IS EQUIPPED WITH TRANSPORTER PROTEINS THAT RAPIDLY TAKE NMN INTO THE BODY, AND WHEN NMN ENTERS THE BODY BY MOUTH, IT IS QUICKLY TAKEN INTO THE BLOODSTREAM AND CONVERTED TO NAD.
[citation]
"Anti-aging Substances that Slow Aging and Continue Vigor, Latest Research Shows Interview with Shinichiro Imai, Professor, University of Washington (top)"
Nikkei Gooday 30+. February 1, 2021
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4. NMN CAN BE SAFELY INGESTED WITHOUT REPORTED SIDE EFFECTS!
So far, we have talked about the potential benefits of NMN intake and application for anti-aging and maintaining youthfulness, and introduced NAD+, but does NMN have any side effects?
In conclusion, NMN has been reported to be safely absorbed and metabolized by our bodies in a joint human clinical study conducted by Keio University and the University of Washington.
A clinical study was conducted on 10 healthy men to determine if NMN can be safely administered to humans.
NMN in healthy humans,
1. can be safely administered
2. is metabolized by the body according to the dose administered
was confirmed.
In addition, the fact that it is an ingredient that is naturally present in the cells of us humans and all other living organisms is also a reassuring factor.
[See]
Authors: Jun-ichiro Irie, Emi Inagaki, Masataka Fujita, Hideaki Nakatani, Masanori Mitsuishi, Shintaro Yamaguchi, Kazuya Yamashita, Shuhei Shigaki, Takashi Ono, Hideo Yukioka, Eiyuki Okano, Yoichi Nabeshima, Shinichiro Imai, Masato Yasui, Kazuo Tsubota , Hiroshi Ito.
"Effects of oral nicotinamide mononucleotide administration on clinical parameters and nicotinamide metabolites in healthy Japanese men."
Papers. 2019-11-2
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In addition, as of October 2021, there have been no reports of any side effects of any kind, either in humans or animals.
5. the amount of NMN that is acceptable to take per day is 10,000 mg
You want to take as much NMN as possible for its anti-aging effect! I know you want to take as much NMN as possible in hopes of anti-aging effects. However, it does not mean that the more you take without limit, the better.
Research at Keio University has demonstrated that 100mg, 250mg, and 500mg of NMN per day can be absorbed without any problem. In addition, human clinical studies at Osaka University confirmed human safety even at 1,000 mg. In fact, some leading NMN researchers have publicly stated that they take 1,000 mg per day.
In addition, INFINIXX tested for toxicity by administering NMN to mice as part of an acute oral toxicity study, and no toxicity was observed even when the maximum dose was administered. The maximum dose of NMN given at this time was 10,000 mg per day in terms of humans. In other words, it is safe to consume 10,000 mg per day.
Why is it safe to ingest in such large quantities?
It is because NMN is a component that is originally present in humans. Also, when we are young, we retain a lot of NMN in our bodies, so there is no problem even if we supplement large amounts.
However, even if you take more than 10,000 mg per day, NMN that cannot be taken into the body may be excreted as urine.
6. "THE RELATIONSHIP BETWEEN NMN AND LONGEVITY GENES" AS SEEN THROUGH ORIGINAL RESEARCH
INFINIXX, the company that distributes this article, conducted a test to measure the effect of NMN on the longevity gene (sirtuin gene).
The content of the study was to "take NMN supplements for 3 months and measure the changes in sirtuin gene activity over a period of 20 times.
The test results showed that the average increase was 1.2 in the case of supplements that can be taken at 100 mg per day, and an average increase of 1.6 in the case of supplements that can be taken at 300 mg per day.
When the sirtuin gene is activated, it can be expected to extend lifespan and slow the aging process.
THIS SHOWS THAT TAKING NMN IS THE KEY TO ANTI-AGING CARE.
6-1. WHAT ARE THE EFFECTS OF SIRTUIN GENE ACTIVATION BY NMN?
When the sirtuin gene is activated, the number of mitochondria that produce energy sources in the cell increases, and abnormal proteins in the cell and old mitochondria are removed.
This action of renewal in cells is called "autophagy," which rejuvenates cells in the same way that mechanical equipment in a factory is renewed. Autophagy has a positive effect on the removal of reactive oxygen species that damage cells, cell repair, the burning of fat, the maintenance of spots and wrinkles, and even the maintenance of health.
In addition, there are 70 to 100 parameters that measure the health of the human body, and most of them can be improved by activating the sirtuin gene.
IN OTHER WORDS, BY TAKING NMN AND ACTIVATING THE SIRTUIN GENE, WE CAN EXPECT GREAT BENEFITS SUCH AS EXTENDING LIFE SPAN AND SLOWING DOWN THE AGING PROCESS.
Summary
NMN is attracting worldwide attention as the key to anti-aging and youthfulness.
Even though NMN is a cutting-edge and remarkable ingredient, it is a substance that originally exists in our bodies. Therefore, you can use NMN supplements and NMN serums without worrying about side effects.
If you want to live a fresher and more resilient life, or if you want to aim for a more resilient and firmer body, please try to take advantage of these products.
