NMN HAS BECOME A HOT TOPIC IN RECENT YEARS AS AN ANTI-AGING INGREDIENT; THE REJUVENATING EFFECTS OF NMN HAVE ATTRACTED WORLDWIDE ATTENTION SINCE ITS ANNOUNCEMENT BY A PROFESSOR OF MEDICINE AT THE UNIVERSITY OF WASHINGTON IN 2016, AND RESEARCH CONTINUES TO THIS DAY.
NMN IS NATURALLY PRODUCED IN THE BODY, BUT SINCE IT DECLINES WITH AGE, IT IS EFFECTIVE TO TAKE NMN FROM FOODS OR SUPPLEMENTS THAT CONTAIN NMN.
IN THIS ARTICLE, WE WILL INTRODUCE THE RELATIONSHIP BETWEEN NMN AND THE PREVENTION OF AGING, AS WELL AS THE EFFECTS THAT CAN BE EXPECTED, GUIDELINES FOR INTAKE AMOUNTS, AND TYPICAL FOODS THAT CONTAIN NMN.
1. NMN IS A VITAMIN
NMN STANDS FOR "NICOTINAMIDE MONONUCLEOTIDE," A SUBSTANCE SIMILAR TO A VITAMIN.
NMN IS UTILIZED AS A SOURCE OF CELLULAR ENERGY, AND THE MORE COENZYME "NAD" PRODUCED FROM NMN, THE MORE YOUTHFUL CELLS CAN BE MAINTAINED.
NMN IS A COMPONENT PRODUCED NATURALLY IN THE BODY, BUT DECREASES WITH AGE.
It is believed that this causes aging, which leads to various changes such as loss of physical strength, deterioration of physical condition, and disease.
FOR THIS REASON, IN RECENT YEARS, MORE AND MORE PEOPLE ARE CONSIDERING ACTIVELY TAKING NMN FROM SUPPLEMENTS AND INTRAVENOUS INFUSIONS TO PREVENT AGING.
1-1. NMN IS SAID TO SUPPORT THE PHYSICAL ENVIRONMENT BY CHANGING TO NAD+.
NMN HAS BEEN ATTRACTING ATTENTION AS AN ANTI-AGING COMPONENT, BUT IT IS THE NAD+ COMPONENT THAT ACTUALLY WORKS TO PREVENT AGING.
NAD+ STANDS FOR (NICOTINAMIDE ADENINE DINUCLEOTIDE), AN ESSENTIAL COMPONENT FOR ENERGY PRODUCTION IN CELLS.
NAD+ IS CLOSELY RELATED TO THE SIRTUIN GENE, WHICH IS KNOWN AS A GENE THAT CONTROLS AGING, AND IT IS SAID THAT THE MORE NAD+ THERE IS, THE MORE ACTIVE THE SIRTUIN GENE IS, IN OTHER WORDS, THE MORE YOUTHFUL WE STAY.
HOWEVER, SINCE NAD+ IS TOO LARGE IN MOLECULAR WEIGHT, IT IS NOT POSSIBLE TO INCREASE NAD+ BY INGESTING IT AS IT IS. FOR THIS REASON, NMN, A PRECURSOR OF NAD+, IS ATTRACTING ATTENTION.
NMN IS THOUGHT TO CHANGE INTO NAD+ WHEN ABSORBED INTO THE BODY, SUPPORTING THE MAINTENANCE OF BODILY FUNCTIONS AND ENZYME FUNCTIONS.
RESEARCH HAS ALSO SHOWN THAT NAD+ ACTIVATES CELLS AND CAN BE EXPECTED TO HAVE THE FOLLOWING EFFECTS.
Anti-aging
INCREASED NAD+ ACTIVATES THE SIRTUIN GENE AND CELLS, WHICH IS VERY EFFECTIVE IN PREVENTING AGING. THE SIRTUIN GENE IS AN IMPORTANT GENE FOR PREVENTING AGING, AND IT WORKS TO REPAIR AGING DNA. IT IS ALSO CALLED THE "LONGEVITY GENE" BECAUSE IT IS EXPECTED TO PROLONG LIFE.
Effect of improved muscle strength
NAD+ IS EXPECTED TO IMPROVE DIABETES, COGNITIVE DECLINE, AND MUSCLE STRENGTH ASSOCIATED WITH AGING. SIGNIFICANT IMPROVEMENTS IN WALKING SPEED AND GRIP STRENGTH HAVE ALSO BEEN OBSERVED IN ELDERLY PEOPLE TAKING NMN ORALLY.
Sleep Improvement
RESEARCH ON NMN AND SLEEP HAS SHOWN THAT THE LEVEL OF SOUND SLEEP, SLEEP QUALITY, RELAXATION, AND WAKEFULNESS ALL INCREASED BEFORE AND TWO WEEKS AFTER NMN INTAKE.
THIS SUGGESTS THAT AN INCREASE IN NAD+ IS ALSO EFFECTIVE IN IMPROVING SLEEP.
Supports the prevention of physical decline
INCREASED NAD+ NOT ONLY IMPROVES CELL AND TISSUE FUNCTION, BUT ALSO EFFECTIVELY IMPROVES LOWER EXTREMITY FUNCTION. THEREFORE, IT IS EFFECTIVE IN SUPPORTING THE MAINTENANCE OF PHYSICAL PERFORMANCE AND THE PREVENTION OF DECLINE.
Supporting physical performance also helps prevent diseases and illnesses associated with aging.
SLEEPINESS AND FATIGUE IN THE ELDERLY CAN DECREASE THEIR QUALITY OF LIFE. HOWEVER, INCREASED NAD+ IMPROVES SLEEP QUALITY AND CAN BE EXPECTED TO PREVENT DAYTIME SLEEPINESS. INCREASED NAD+ ALSO MAKES PHYSICAL PERFORMANCE LESS SUSCEPTIBLE TO DECLINE, AND PHYSICAL AND MENTAL FATIGUE IS MORE EASILY RESOLVED. ALTHOUGH VERIFICATION AND RESEARCH ON THE ANTI-AGING EFFECTS OF NMN ARE BEING CONDUCTED AROUND THE WORLD, THE EFFECTIVE DOSAGE IS NOT YET CLEAR. There are various theories and studies that suggest a daily dosage of 125 mg, 8 mg x body weight, etc. Some studies and clinics suggest a daily dosage of 1,000 mg or more. Celebrities such as Takafumi Horie, a.k.a. Holliemon, and Professor Sinclair, author of "LIFESPAN: A World Without Aging," also seem to take about 1,000 mg per day. In a clinical experiment conducted by the University of Tokyo, improvements in muscle strength and performance were observed in elderly men who orally ingested 250 mg of NMN per day for 12 weeks. A CHINESE STUDY OF AMATEUR RUNNERS AGED 27-50 ALSO FOUND NO SAFETY ISSUES AFTER 6 WEEKS OF CONSUMPTION OF 1,200 MG OF NMN PER DAY. Nevertheless, since studies at the University of Tokyo and the University of Tsukuba, among others, are currently using 250 mg, 250 mg is a good guideline. NMN CAN BE TAKEN FROM THE NORMAL DIET, BUT IN ONLY A SMALL AMOUNT. IN ADDITION, NMN IS HEAT-SENSITIVE, SO TAKING SUPPLEMENTS IN COMBINATION IS SAID TO BE EFFECTIVE. BELOW ARE TYPICAL FOODS THAT CONTAIN NMN AND THEIR NMN CONTENT. It is said that edamame contains 0.47 to 1.88 mg of NMN in 100 g of soybeans. To consume 250 mg, which is the standard intake amount, you need to eat 53.2 kg or about 82,500 edamame per day. It is said that 100 g of broccoli contains 0.25 to 1.12 mg of NMN. To consume 250 mg, which is the standard intake amount, one would have to eat 100 kg or about 5,000 bunches of broccoli per day. It is said that 100 g of avocados contain 0.36 to 1.60 mg of NMN. To consume 250 mg, which is the standard intake, one would need to eat 69.4 kg or about 555 avocados per day. It is said that 100 g of tomatoes contain 0.26 to 0.30 mg of NMN. To consume 250 mg, which is the standard intake amount, one would have to eat 96.2 kg of tomatoes per day, or about 633 medium-sized tomatoes. AS MENTIONED ABOVE, NMN CONTAINED IN FOOD IS IN MINUTE QUANTITIES AND MUST BE TAKEN WITHOUT HEAT, AS NMN IS HEAT SENSITIVE. THEREFORE, IT IS NOT REALISTIC TO TRY TO SUPPLEMENT NMN BY DIET ALONE, AND IT IS RECOMMENDED TO SUPPLEMENT FROM BOTH SUPPLEMENTS AND FOODS*. *Strictly speaking, supplements are also included in food, but we describe food ingredients as food here. NMN IS ONE OF THE SUBSTANCES SIMILAR TO VITAMINS THAT CAN BE CONVERTED TO NAD+ IN THE BODY TO PREVENT AGING, IMPROVE MUSCLE STRENGTH AND SLEEP, SUPPORT PHYSICAL PERFORMANCE, AND MUCH MORE. NMN IS ALSO FOUND IN FOODS SUCH AS BROCCOLI AND EDAMAME, BUT IT IS HEAT SENSITIVE AND MUST BE EATEN UNCOOKED, AND THE AMOUNT OF NMN THAT CAN BE INGESTED IS MINUTE. THEREFORE, SUPPLEMENTS ARE THE MOST COMMON WAY TO SUPPLEMENT NMN. However, the effective intake is not yet clear. Some studies use 1,200 mg per day, but clinical experiments at the University of Tokyo have shown improvements in muscle strength and performance with 250 mg of NMN per day. For this reason, it is advisable to start with a daily intake of 250 mg as a standard from supplements or diet. Prevention of drowsiness and relief of fatigue
2. WHAT IS THE RECOMMENDED INTAKE OF NMN?
3. TYPICAL FOODS CONTAINING NMN ARE INTRODUCED.
edamame (green soybeans)
broccoli
avocado (Persea americana)
tomato
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