NMN, WHICH IS EXPECTED TO PREVENT AGING AND REJUVENATE THE BODY, HAS BECOME A HOT TOPIC IN RECENT YEARS. HOWEVER, SOME PEOPLE MAY HAVE CONCERNS ABOUT ITS SAFETY AND SIDE EFFECTS WHEN CONSIDERING TAKING NMN.
HERE, WE WILL DISCUSS THE SPECIFIC BENEFITS AND SAFETY OF NMN, BASED ON VARIOUS PAPERS AND STUDIES; IF YOU ARE CONCERNED ABOUT THE EFFECTS AND SIDE EFFECTS OF TAKING NMN, PLEASE REFER TO THIS SECTION.
1. NMN IS A VITAMIN
NMN stands for Nicotinamide MoNoncleotide, which is a component similar to vitamin B3.
THE HUMAN BODY MAKES TRACE AMOUNTS OF NMN FROM VITAMIN B3, AND NMN IN THE BODY IS CONVERTED TO NAD+ (NICOTINAMIDE ADENINE DINUCLEOTIDE).
NAD+ IS A COMPONENT THAT ACTIVATES THE SIRTUIN GENE (LONGEVITY GENE) IN THE BRAIN AND IS ESSENTIAL FOR MAINTAINING YOUTH AND HEALTH. THEREFORE, INCREASING THE AMOUNT OF NMN IN THE BODY IS CONSIDERED TO BE ONE EFFECTIVE MEANS OF PREVENTING AGING AND MAINTAINING HEALTH.
NMN CAN BE OBTAINED MAINLY THROUGH DIET, SUPPLEMENTS, AND INTRAVENOUS INFUSION (UNDER THE SUPERVISION OF A DOCTOR AT A CLINIC, ETC.).
THERE ARE THREE MAIN EFFECTS THAT CAN BE EXPECTED FROM NMN INTAKE. THE FOLLOWING IS AN EXPLANATION OF THE SPECIFIC EFFECTS OF CONTINUOUS NMN INTAKE ON THE BODY.
- Prevention of aging
- Disease Prevention
- Aesthetic approach
1-1. Prevention of Aging
IT IS SAID THAT PROBLEMS ASSOCIATED WITH AGING MAY BE PREVENTED BY THE INTAKE OF NMN. THESE ARE MAINLY DECLINES IN PHYSICAL FUNCTIONS SUCH AS PHYSICAL STRENGTH. POOR SLEEP QUALITY AND REDUCED CONCENTRATION ARE SEEN WITH AGING, AND NMN IS EXPECTED TO HAVE A PREVENTIVE EFFECT ON THESE PROBLEMS.
IT IS ALSO KNOWN THAT NMN IN THE BODY IS SAID TO DECREASE TO HALF OF WHAT IT WAS WHEN THE BODY WAS YOUNG IN THE LATE 50S, AND THAT THIS IS ACCOMPANIED BY A DECREASE IN NAD+, WHICH LEADS TO THE AGING PROCESS. SINCE THE AGING PROCESS IS A RISK FACTOR FOR VARIOUS DISEASES, PREVENTION OF AGING THROUGH NMN INTAKE HAS THE POTENTIAL TO PROVIDE MANY HEALTH BENEFITS.
1-2. Disease Prevention
NMN MAY ALSO HELP MAINTAIN GOOD HEALTH, WHICH MAY RESULT IN DISEASE PREVENTION.
SOME OF THE HEALTH BENEFITS EXPECTED FROM NMN CONSUMPTION INCLUDE THE FOLLOWING
- Improved immune function
- Improved metabolism
- Prevention of Obesity
DISEASES THAT CAN BE EXPECTED TO BE PREVENTED BY NMN INTAKE (WHICH CAN BE CAUSED BY A DECLINE IN BODILY FUNCTIONS, ETC.) INCLUDE THE FOLLOWING
- dementia
- diabetes mellitus
- Cardiac and cerebrovascular diseases associated with arteriosclerosis
- Eye disease, etc.
1-3. Approach to cosmetic aspects
SKIN PROBLEMS SUCH AS SPOTS, WRINKLES, AND SAGGING ARE CAUSED BY VARIOUS FACTORS SUCH AS UNBALANCED DIET AND INCORRECT SKIN CARE. ONE OF THE MOST COMMON FACTORS IS AGING, AND NMN INTAKE INCREASES NAD+ AND ACTIVATES THE SIRTUIN GENE, WHICH HELPS TO PROMOTE HEALTHY SKIN.
THOSE WHO SUFFER FROM LOSS OF FIRMNESS AND LUSTER AND DULLNESS DUE TO AGING MAY WANT TO TAKE NMN TO IMPROVE THE FOUNDATION OF BEAUTIFUL SKIN. IN TERMS OF BEAUTY, THERE ARE REPORTS THAT METHODS TO PENETRATE NMN THROUGH THE SKIN ARE ALSO EFFECTIVE, AND IN RECENT YEARS, SKINCARE PRODUCTS USING NMN HAVE ALSO BEEN SEEN.
See also: NMN has anti-aging effects in serums and other skin care products!
2. ARE THERE ANY SIDE EFFECTS OF NMN INTAKE?
NMN MAY ALSO HELP MAINTAIN GOOD HEALTH, WHICH MAY RESULT IN DISEASE PREVENTION.
SOME OF THE HEALTH BENEFITS EXPECTED FROM NMN CONSUMPTION INCLUDE THE FOLLOWING
NO SERIOUS SIDE EFFECTS FROM NMN INGESTION HAVE BEEN REPORTED TO DATE.
*AS OF SEPTEMBER 2022, APPROXIMATELY 90% OF THE RAW MATERIALS FOR NMN INFUSIONS ADMINISTERED AT CLINICS NATIONWIDE ARE PROVIDED BY NORDESTE INC. THERE HAVE BEEN NO REPORTS OF SIDE EFFECTS WITH RESPECT TO THESE NMN INFUSIONS.
HOWEVER, WHEN NMN INFUSION IS USED, THERE IS A POSSIBILITY OF INFUSION-SPECIFIC SIDE EFFECTS; THE TWO MOST COMMON SIDE EFFECTS SEEN WITH INFUSION, NOT LIMITED TO NMN, ARE VASCULAR PAIN AND REDNESS OR RASH.
VARIOUS STUDIES AND PAPERS HAVE BEEN PUBLISHED ON THE SAFETY AND SIDE EFFECTS OF NMN SINCE THE DISCOVERY OF THE NAD+ EFFECT IN 2013. SOME OF THE OLDER PAPERS WERE ON MAMMALS, SUCH AS MICE, BUT HERE ARE SOME OF THE MOST RECENT STUDIES AND PAPERS ON HUMANS.
2-1. Keio University School of Medicine (2016-2020)
THIS IS A STUDY OF 10 HEALTHY MEN TO DETERMINE HOW ADMINISTRATION OF NMN AFFECTS PEOPLE. THE STUDY CONFIRMED THAT NMN CAN BE SAFELY ADMINISTERED TO HEALTHY PEOPLE, AT LEAST UP TO ABOUT 500 MG PER DAY.
Reference: https: //www.keio.ac.jp/ja/press-releases/files/2020/1/21/200121-1.pdf
2-2. Joint research with University of Tsukuba and Japan Society for the Promotion of Science (February 2022)
This study investigated the effects of NMN intake in 108 elderly subjects. Continuous intake of NMN once a day (250 mg) for 12 weeks was shown to improve physical function and fatigue, with no serious side effects or adverse effects.
Reference: https: //pubmed.ncbi.nlm.nih.gov/35215405/
2-3. Research at the University of Tokyo Hospital (May 2022)
This study investigated the effects of oral NMN on the aging process in 42 healthy men over the age of 65. After administering 250 mg of NMN per day to elderly men for 12 weeks, the results showed safety and an increase in NAD+.
Reference: https: //project.nikkeibp.co.jp/behealth/atcl/feature/00043/061300013/
2-4. STUDY OF NMN MANUFACTURER IN SHANGHAI (MAY 2022)
This is a clinical trial of NMN conducted on 66 healthy men and women between the ages of 40 and 65. The study confirmed the safety of continuous intake of 300 mg of NMN, as well as the effects of increased NAD+, improved walking ability, and increased well-being.
Reference: https: //www.kenko-media.com/health_idst/archives/16369
3. IS THERE A CANCER RISK INDICATED FOR NMN?
VARIOUS STUDIES HAVE SHOWN NMN TO BE SAFE, BUT SOME ARE CONCERNED ABOUT THE RISK OF CANCER.
THE REASON WHY THERE IS CONCERN ABOUT THE RISK OF CANCER WHEN NMN IS INGESTED IS THAT THERE IS MIXED INFORMATION ABOUT CANCER AND NAD+, INCLUDING THE FACT THAT MANY ENZYMES THAT SYNTHESIZE NAD+ ARE FOUND IN CANCER CELLS.
HOWEVER, THERE HAVE BEEN NO CONFIRMED CANCER-CAUSING EVENTS IN MOUSE EXPERIMENTS WITH NMN, AND MANY OF THE LATEST STUDIES REPORT THAT NMN DOES NOT CARRY A CANCER RISK.
IN THE CASE OF NMN, RATHER, ITS ANTI-AGING EFFECT HAS BEEN CONFIRMED WHEN TAKEN BY MAMMALS (MICE) AND HUMANS, AND MANY PAPERS HAVE BEEN PUBLISHED THAT RECOGNIZE ITS BENEFICIAL EFFECTS, ESPECIALLY IN GENERATIONS WHERE NMN IS DECLINING.
A UNIVERSITY OF TOYAMA PAPER PUBLISHED IN 2018 CONFIRMED THAT INHIBITING THE ENZYME THAT SYNTHESIZES NAD+ INHIBITS CANCER CELL GROWTH.
4. Summary
MANY STUDIES HAVE REPORTED THAT NMN IS A SAFE INGREDIENT TO TAKE IN, WITH NO SERIOUS SIDE EFFECTS HAVING OCCURRED TO DATE. INGESTED NMN IS CONVERTED TO NAD+ IN THE BODY, WHICH PLAYS AN ESSENTIAL ROLE IN THE PREVENTION OF AGING. AT THIS TIME, NMN HAS BEEN SHOWN TO HAVE LITTLE RISK OF ADVERSE HEALTH EFFECTS OR CANCER.
SUPPLEMENT NMN, WHICH DECLINES WITH AGE, WITH SUPPLEMENTS OR INTRAVENOUS INFUSIONS (UNDER THE SUPERVISION OF A PHYSICIAN) TO KEEP YOUR BODY FROM AGING OR BECOMING ILL.
