NMN IS ATTRACTING ATTENTION FROM RESEARCHERS AROUND THE WORLD FOR ITS POTENTIAL ANTI-AGING EFFECTS.
NMN stands for "Nicotinamide MonoNucleotide," a substance found in the cells of all living organisms, including humans.
HOWEVER, IT IS BELIEVED THAT NMN IN THE BODY DECREASES WITH AGE, RESULTING IN VARIOUS PHYSICAL CHANGES.
SO HOW DOES NMN EXERT ITS ANTI-AGING EFFECTS IN THE BODY?
IN THIS ISSUE, WE WILL INTRODUCE THE REASONS WHY NMN IS CONSIDERED TO BE "REJUVENATING," AS WELL AS THE EFFECTS THAT CAN BE EXPECTED FROM NMN INTAKE AND THE RECOMMENDED DOSAGE.
1. WHY NMN IS SAID TO REJUVENATE THE BODY
NMN TAKEN IN THROUGH DIET OR SUPPLEMENTS IS CONVERTED IN THE BODY TO NAD+ (NICOTINAMIDE ADENINE DINUCLEOTIDE) NAD+ IS A COENZYME ESSENTIAL FOR ENERGY PRODUCTION, AND WHEN NAD+ IS DEPLETED, ORGANISMS ARE BASICALLY UNABLE TO SURVIVE.
IN ADDITION, NAD+ HAS ANOTHER IMPORTANT ROLE. THAT IS THE ACTIVATION OF THE SIRTUIN GENE. SIRTUINS ARE GENES THAT CONTROL AGING AND LIFESPAN, AND ARE ALSO KNOWN AS "LONGEVITY GENES.
THE EFFECTS OF AGING ARE INEVITABLE FOR NAD+ AS WELL, AND LIKE NMN, IT DECLINES WITH AGE, AND IN ONE'S 40S, IT IS REDUCED TO ABOUT HALF OF WHAT IT WAS IN ONE'S LATE TEENS. FURTHERMORE, NAD+ IS NOT EASILY ABSORBED INTO THE BODY EVEN WHEN DIRECTLY INGESTED.
THE SOLUTION TO THESE PROBLEMS IS NMN, A PRECURSOR OF NAD+, AND INCREASING THE AMOUNT OF NAD+ IN THE BODY MAY LEAD TO ACTIVATION OF THE SIRTUIN GENE, THEREBY REDUCING AGE-RELATED CHANGES IN BODILY FUNCTIONS.
1-1. What is the sirtuin gene, which is closely related to rejuvenation?
Let's learn a little more about the sirtuin gene, which is closely related to human aging and lifespan.
The sirtuin gene is a gene that is expressed in large numbers in the hypothalamus of the brain. It is usually not very active, but is known to become active when starvation occurs due to caloric restriction.
There are four major functions of the sirtuin gene
- CONTROL OF DNA REPAIR, ETC.
- Control of energy metabolism
- Control of cell division
- Control of genes related to the body clock
IT HAS BEEN SHOWN THAT WHEN ACTIVATED SIRTUIN GENES ACT ON AGING CELLS, DNA IS REPAIRED AND CELLS ARE "REJUVENATED".
HUMANS HAVE SEVEN TYPES OF SIRTUIN GENES, AND NAD+ IS SAID TO ACTIVATE ALL SEVEN SIRTUIN GENES.
2. REJUVENATION EFFECT OF NMN
NMN HAS BEEN REPORTED TO HAVE VARIOUS EFFECTS, INCLUDING DISEASE PREVENTION AND INHIBITION OF THE AGING PROCESS.
EXPERIMENTS CONDUCTED ON MICE AT THE UNIVERSITY OF WASHINGTON DEMONSTRATED A NUMBER OF ANTI-AGING EFFECTS, SUCH AS SUPPRESSION OF GENETIC CHANGES THAT SHOULD OCCUR WITH AGING BY ADMINISTRATION OF NMN.
A HARVARD UNIVERSITY STUDY ALSO REPORTED THAT WHEN NMN WAS ADMINISTERED TO 22-MONTH-OLD MICE (ABOUT 60 YEARS OLD IN HUMANS), ONE WEEK LATER, THEIR MUSCLES WERE REJUVENATED TO THE STATE OF 6-MONTH-OLD MICE.
OTHER STUDIES ARE UNDERWAY AT VARIOUS UNIVERSITIES AND MANY PAPERS HAVE BEEN PUBLISHED ON THE REJUVENATING EFFECTS OF NMN.
HERE ARE SOME OF THE REJUVENATING EFFECTS THAT CAN BE EXPECTED FROM NMN.
2-1. Improvement of physical strength
MORE THAN 90% OF THE ENERGY REQUIRED FOR CELLULAR ACTIVITY IS PRODUCED IN THE MITOCHONDRIA, AND NAD+, OBTAINED BY TAKING NMN, IS A COENZYME ESSENTIAL FOR MITOCHONDRIAL ENERGY PRODUCTION.
TAKING NMN CAN BE EXPECTED TO IMPROVE PHYSICAL FITNESS BY SMOOTHING ENERGY PRODUCTION, INCREASING METABOLISM, AND MAKING IT HARDER TO CATCH YOUR BREATH DURING EXERCISE.
IN ADDITION, A STUDY OF ELDERLY MEN AGED 65 YEARS AND OLDER SUGGESTED THAT NMN MAY HELP IMPROVE MOTOR FUNCTION AND MUSCLE STRENGTH IN THE ELDERLY.
2-2. Improvement of sleep quality
IT IS BELIEVED THAT NMN INTAKE IMPROVES SLEEP QUALITY AS ENERGY METABOLISM INCREASES AND BREATHING BECOMES EASIER. IN FACT, A STUDY OF MEN AND WOMEN OVER 65 YEARS OF AGE FOUND SIGNIFICANT IMPROVEMENTS IN SLEEP QUALITY WITH NMN INTAKE.
GETTING ENOUGH SLEEP AT NIGHT IS IMPORTANT FOR PREVENTING AGING, AND THE ANTI-AGING EFFECT OF NMN IS HIGHLY APPRECIATED IN THIS RESPECT.
2-3. Increase in estrogen
NMN IS ALSO BELIEVED TO INCREASE ESTROGEN, A TYPE OF FEMALE HORMONE.
ESTROGEN IS A HORMONE THAT IS CLOSELY ASSOCIATED WITH AGING, ESPECIALLY IN WOMEN; IF ESTROGEN INCREASES WITH NMN INTAKE, IT CAN BE EXPECTED TO PREVENT BONE FRACTURES AND OTHER AGING-RELATED DISEASES, REDUCE MENOPAUSAL SYMPTOMS, AND IMPROVE SKIN PROBLEMS.
WOMEN ARE NOT THE ONLY ONES WHO BENEFIT FROM THE ESTROGEN INCREASE CAUSED BY NMN. ESTROGEN IS ALSO PRESENT IN THE MALE BODY AND PLAYS AN IMPORTANT ROLE IN MAINTAINING BONE MASS. BECAUSE TOO LITTLE ESTROGEN MAKES IT DIFFICULT FOR MEN TO MAINTAIN BONE HEALTH, NMN MAY ALSO HELP PREVENT OSTEOPOROSIS IN MEN.
2-4. Increased ability to think and concentrate
SOME PEOPLE SAY THAT TAKING NMN CLEARS THEIR HEADS AND IMPROVES THEIR ABILITY TO THINK AND CONCENTRATE.
The brain is prone to decline in function if it is not used. However, when you focus on thinking and working, the brain's network of nerve cells becomes denser, helping to prevent brain aging.
IMPROVING THINKING AND CONCENTRATION WITH NMN WILL HELP KEEP THE BRAIN YOUNG AND ACTIVE FOR LIFE.
3. WHAT IS THE RECOMMENDED INTAKE OF NMN?
SO WHAT IS THE STANDARD AMOUNT OF NMN INTAKE?
Since NMN is not a drug, there is no specific amount to take, but based on reports from past clinical trials, it is generally considered ideal to take about 100 to 300 mg of NMN per day.
The amount of NMN administered to mice at the University of Washington is about 8 mg per kg of body weight in human terms, or about 560 mg for a 70 kg person.
Clinical trials on humans at Osaka University have confirmed the safety of taking 1,000 mg of NMN per day, so some believe that this is definitely not too much.
NMN is also found in edamame, cucumbers, broccoli, etc., but only a very small amount can be obtained from food. For example, to consume 100 mg of NMN from edamame, one would have to eat about 21 kg (about 33,000 grains). Therefore, if you want to take NMN for its rejuvenating and anti-aging effects, it is more realistic to take supplements.
4. Summary
NMN IS A SUBSTANCE THAT EXISTS IN THE BODIES OF ALL LIVING ORGANISMS, INCLUDING HUMANS, AND IS BY NO MEANS SPECIAL. HOWEVER, AS THE BODY'S NMN LEVEL DECREASES WITH AGE, VARIOUS AGE-RELATED CHANGES OCCUR.
THE REASON WHY IT IS SAID THAT "NMN MAKES YOU YOUNGER" IS BECAUSE NAD+, A COENZYME CHANGED FROM NMN, ACTIVATES THE SIRTUIN GENE (LONGEVITY GENE) AND SHOWS VARIOUS ANTI-AGING EFFECTS. THE EFFECTS ARE DIVERSE, AND VARIOUS ANTI-AGING AND REJUVENATING EFFECTS HAVE BEEN REPORTED, INCLUDING IMPROVEMENT OF PHYSICAL FITNESS, IMPROVEMENT OF SLEEP QUALITY, INCREASE IN ESTROGEN, AND ACTIVATION OF THE BRAIN.
To obtain these benefits, it has been shown that a good rule of thumb is to start with about 100-300 mg of NMN per day; NMN is also found in foodstuffs, but supplements are recommended for efficient intake of the required amount.
WITH ITS POTENTIAL FOR HEALTH AND LONGEVITY, NMN HAS THE POTENTIAL TO BE AN IDEAL INGREDIENT FOR US.
