1. WHAT IS NMN IN THE FIRST PLACE?
NMN, officially called "nicotinamide mononucleotide," is a substance similar to a vitamin that is produced naturally in our bodies. However, as we age, the production of NMN gradually decreases, and it is believed that aging begins when NMN is depleted in the body, and aging proceeds.
In recent years, NMN has been attracting attention as a "rejuvenation drug," especially among scientists and people interested in beauty around the world.
NMN IS ATTRACTING ATTENTION AS A KEY TO "REJUVENATION
Study after study has found that taking NMN causes dramatic changes in the appearance and function of the body, just like turning back the hands of a clock.
Genes associated with anti-aging and anti-aging care are called "sirtuin genes," and NMN supports the creation of beautiful skin by acting on these sirtuin genes.
It is expected that an increase in the amount of NMN in cells will activate the sirtuin gene and restore youthfulness and beauty to the skin.
1-2. NMN INTAKE CAN COMPENSATE FOR THE DECREASE IN NAD+, THE LIVER OF ANTI-AGING.
NMN IS ABSORBED INTO THE BODY AND CONVERTED INTO A COENZYME CALLED NAD+, WHICH IS A SUBSTANCE INVOLVED IN ENERGY ACTIVITY AND IS BELIEVED TO PLAY A KEY ROLE IN ANTI-AGING. NAD+, LIKE NMN, DECLINES IN THE BODY WITH AGE, BUT IT IS KNOWN THAT NAD+ CAN BE SUPPLEMENTED BY SUPPLYING NMN, WHICH IS A MATERIAL FOR NAD+, FROM THE OUTSIDE.
1-3. WHAT IS NAD+?
NAD+ is a chemically altered form of niacin, which is present in the body of all living organisms and influences youthfulness and health maintenance.
When the rejuvenating ingredient NMN is ingested, it is absorbed into the body, delivered throughout the body, and then converted into a coenzyme called NAD+.
The amount of NAD+ begins to decline after peaking in our late teens, and by our 40s it is reduced to half its peak level. Why does it decrease with age? There are various factors, but since NAD+ is necessary for the repair of DNA damage, one reason is that as we age, the number of areas that need repair by NAD+ increases, resulting in a depletion of NAD+. And as the amount of NAD+ decreases, the body loses its youthfulness.
In other words, by maintaining and increasing NAD+ levels in the body, energy production and sirtuin gene activation can be stimulated, and youthfulness can be restored.
1-4. INCREASING NAD+ IN YOUR SKIN IS A SHORTCUT TO YOUTHFULNESS
NAD+ is an ingredient that fuels and activates the sirtuin gene.
As mentioned in the previous section, the sirtuin gene is a gene that is very closely related to the development of youthful and beautiful skin. In other words, the more NAD+ in your skin, the more it will change to a firm and tight skin.
1-5. SUPPLEMENT NAD+ WITH NMN
If aging is caused by the loss of NAD+, wouldn't it be best to supplement NAD+ directly? However, this is not efficient because NAD+ itself has a large molecular structure and is difficult to be absorbed into the body.
The most efficient and effective way to maintain NAD+ in the body is to take in NMN, which converts to NAD+.
2. NMN IS ALSO EFFECTIVE IN SKIN CARE!
NMN can be given directly to the body through supplements or intravenous infusions, but also applied to the skin through skin care to provide anti-aging and other wonderful benefits.
If skin care is easy to make routine in your daily life, you can easily incorporate NMN into your skin care routine.
2-1. NMN SOLUTION INCREASES THE AMOUNT OF NMN IN CELLS 100-FOLD!
STUDIES HAVE SHOWN THAT WHEN AQUEOUS NMN SOLUTION IS GIVEN TO THE STRATUM CORNEUM, THE AMOUNT OF NMN IN THE CELLS INCREASES 100-FOLD AND THE AMOUNT OF NAD+ ALSO INCREASES APPROXIMATELY 4-FOLD.
Author：Kenyuki Hattori (Keio Univ.), Ryohei Aoyagi (Keio Univ.), Akira Date
(P&G Japan), Yoshihiro Abe (Keio Univ.), Etsuomi Tamura (Keio Univ.).
"Effect of nicotinic acid amide mononucleotide (NMN), a precursor of NAD biosynthesis, on the differentiation of human skin epidermis". 2013.
AS MENTIONED IN THE PREVIOUS SECTION, NMN AND NAD+ PLAY A ROLE IN INHIBITING SKIN AGING, SO SUPPLEMENTING NMN AND INCREASING NAD+ LEVELS IN THE SKIN IS A SHORTCUT TO BEAUTIFUL SKIN.
2-2. NMN ACTS ON 7 LONGEVITY GENES SIMULTANEOUSLY
Among the 30,000 different genes that make up our bodies are sirtuin genes, which are known as "longevity genes" and "anti-aging genes.
Furthermore, sirtuin genes range from SIRT1 to SIRT7, each of which is believed to be involved in creating tight-fitting skin and nurturing skin that is resistant to aging.
In fact, various skin problems are caused by SIRT1-7 cycle disorders. And to solve them, all seven must be taken care of at the same time, which is possible with NMN!
2-3. NMN IS MORE EFFECTIVE THAN NIACINAMIDE!
Niacinamide" is used in skincare products as a wrinkle-improving ingredient.
NMN is a substance that converts directly to NAD+ when absorbed through the skin. Niacinamide, on the other hand, is a good ingredient, but it takes two steps to convert to NAD+, and the amount of NAD+ in the process is naturally lower.
This shows that NMN is effective in creating young skin.
3. HOW TO CHOOSE AN NMN SERUM
NMN-CONTAINING SERUMS FROM VARIOUS MANUFACTURERS.
WHAT KIND OF NMN SERUMS CAN BE USED EFFECTIVELY? WE WILL TELL YOU THE POINTS TO CHECK WHEN YOU ARE READY TO PURCHASE, AND HOW TO CHOOSE AN NMN SERUM.
3-1. "Nicotinamide mononucleotide" is listed at the top of the ingredients label.
First of all, base ingredients account for about 80% of most cosmetics. Base ingredients include water, moisturizers, and other ingredients that make up the backbone of a cosmetic product.
The remaining 20% are active ingredients.
The rule of ingredient labeling is to list all ingredients, except fragrance and carryover ingredients, in descending order of their composition.
In other words, the higher the NMN content, the more "NMN" or "nicotinamide mononucleotide" is listed at the beginning, after water, glycerin, BG, and other moisturizers, which are the base ingredients. If you want to use a more effective product, choose a serum with "NMN" or "nicotinamide mononucleotide" listed at the beginning of the ingredient label as much as possible.
3-2. SAFE AND HIGH-PURITY NMN IS USED.
EVEN IF A SERUM CONTAINS A LARGE AMOUNT OF NMN, IT IS MEANINGLESS IF ITS QUALITY IS POOR.
Select products from manufacturers whose safety has been proven through third-party inspections such as "raw material authenticity tests" to determine whether raw materials are genuine, "toxicity tests" and "patch tests.
IN ADDITION, THE HIGHER THE PURITY OF NMN, THE HIGHER THE QUALITY. CONVERSELY, THE LOWER THE PURITY, THE MORE IMPURITIES ARE CONSIDERED TO BE MIXED IN AND THE MORE QUESTIONABLE THE SAFETY.
WHEN YOU GET NMN PRODUCTS, YOU SHOULD ALSO PAY ATTENTION TO THEIR PURITY.
3-3. THERE IS A PARTICULAR FOCUS ON INGREDIENTS OTHER THAN NMN.
BECAUSE NMN IS A RARE INGREDIENT THAT IS KEY TO REJUVENATION, IT IS ALSO IMPORTANT THAT THE PRODUCT CONTAINS SUPPORTIVE INGREDIENTS THAT MAXIMIZE ITS EFFECTIVENESS.
For example, we recommend products that contain "growth factors (peptides)," which refer to proteins that promote the differentiation and activity of certain cells in the animal body, and high-quality "stem cell extracts," which are employed in the field of beauty science.
WHEN SELECTING AN NMN SERUM, PLEASE PAY ATTENTION TO INGREDIENTS OTHER THAN NMN.
3-4. INGREDIENTS THAT YOU WOULD LIKE TO SEE IN NMN SERUMS
IN THE PREVIOUS SECTION, WE MENTIONED THAT THE KEY TO SELECTING AN NMN SERUM IS "WHETHER OR NOT IT IS PARTICULAR ABOUT INGREDIENTS OTHER THAN NMN.
■Human gene-like bio-based peptides
SIRT1 (human recombinant polypeptide-66), SIRT2 (human recombinant polypeptide-67), Prospin (nicotinoyl hexapeptide-44), and aquaporin (synthetic human recombinant polypeptide-64).
■ Growth Factors
EGF (HUMAN RECOMBINANT OLIGOPEPTIDE-1), PGF (SYNTHETIC HUMAN RECOMBINANT POLYPEPTIDE-16), IGF-2 (SYNTHETIC HUMAN RECOMBINANT POLYPEPTIDE-31), ETC.
■Human amniotic fluid cell acclimation culture medium
This ingredient has been called a rejuvenating factor in a Harvard study and is attracting attention in the field of regenerative medicine.
■Human bone marrow stem cell acculturation medium
It is an expert in cell repair and regeneration, which is believed to complement the function of the skin.
■Human fibroblast acclimation culture medium
It tightens skin laxity and helps maintain youthful skin.
■DMAE (DIMETHYLAMINOETHANOL TARTRATE)
It tightens the skin and is used in many anti-aging cosmetics.
■ Allantoin
A popular ingredient often used in cosmetics for people with sensitive skin to prevent skin irritation and acne.
WHEN CHOOSING AN NMN SERUM, ALSO CHECK WHETHER IT CONTAINS THE SUPPORTIVE INGREDIENTS LISTED ABOVE.
3-5. No colorants, mineral oil, etc. are used.
We want to use cosmetics that are gentle to the skin and safe for daily use. This is especially true for items that are first used on skin that has just been cleansed and is in a highly permeable state.
No matter how high the purity of the NMN used and how many wonderful support ingredients are in the product, it will be ruined if it contains colorants, mineral oil, or other additives that are harmful to the human body or can cause skin problems.
Check the ingredient label for the following additives.
■Synthetic perfumes
Volatile alcohols can become toxic aldehydes in the body.
■Synthetic colorants
Tar-based dyes are the most common and are carcinogenic, and some are banned in other countries.
■Paraben (preservative)
Some are carcinogenic and can cause contact dermatitis.
■Mineral oil
It is easily oxidized by heat and open air, and poor quality can cause hyperpigmentation.
■Pelgaptan
Exposure to sunlight can exert phototoxicity, causing skin problems such as staining and inflammation.
■Silicon
The filmy nature makes it difficult for the beauty ingredients to penetrate the skin and causes skin dryness.
The filmy nature of the skin can make it difficult for beauty ingredients to penetrate the skin and cause skin to dry out.
The above do not necessarily have adverse effects just because they are included, but it is recommended that they be listed as far back on the ingredient label as possible, or that they are not added.
3-6. THIRD-PARTY TESTING AND INSPECTION OF NMN RAW MATERIALS
The reality is that NMN, which has raised expectations for its rejuvenating effects, is of variable quality due to its rarity.
The indicator for judging the quality of a product is whether or not it discloses data from third-party testing and inspections.
For example, "NMN raw materials are tested for purity and the information is disclosed," or "NMN raw materials are tested for endotoxin levels on a lot-by-lot basis to confirm safety.
summary
NMN is now available in various ways, such as supplements and intravenous infusions, and we now know that it can be taken directly into the body or given to the skin through skin care products such as serums.
Incorporate NMN serums into your daily skincare regimen to achieve vibrant, youthful-looking skin even after 10 years.
